I would really just be focusing on WoW in general. Since the Warcraft universe and the community that goes with it is so large, I know there would quite a lot to cover and it might get out of hand. Although I'm sure we would just focus on certain news from that week. One topic I don't see done enough is PvP, and I'm not totally sure why that is. That may be a direction I would like to do, but alas, I would hate for someone not to listen to my podcast because "all they talk about is pvp". I would like some variety!
I also noticed that while I'm playing in game I always pick up on little stuff that I had never noticed before. I know there are probably hundreds of podcasts out there with the obvious same topic, but that wouldn't stop me from throwing my hat in the ring. Like I said it is something I have always wanted to do, and considering WoW is one of the few passions I stick to with the same dedication, it only seems natural.
@Relevart, thanks for the response! I've actually thought about perhaps making the co-host something of a revolving door, maybe to keep things interesting? As far as the prerecorded stuff, that would be amazing as well! I will definitely talk to you as soon as I can find someone that will be interested in something of a semi-permanent co-host position.
@Fimlys, yeah I've pretty much exhausted all my guild mates and friends. Everyone so far seems to be terrified to do it ("No, I hate my voice I sound stupid!") or they are pretty unreliable. I've actually had three people that seemed excited to do it, and when I asked them to meet me in vent on a certain day to discuss details, they never showed up.

Thanks for the encouragement, everyone! I have no intentions on stopping my search, and really appreciate everyones response so far!